Pathogenesis of Arteriosclerosis

Pathogenesis of Myocardial and Cerebral Infarction: Nodular Arteriosclerosis.

of his classical article of 1856, which I give as the Appendix to this paper. Virchow was struck by three features of the intimal plaque-the presence of abnormal substances between the cells, the presence of actively dividing cells as in a tumour or in the irritated cornea, and fatty metamorphosis. He thought the abnormal constituents of the ground substance came from the blood, and, since the ...

Experimental Arteriosclerosis

Arteriosclerotic lesions have been produced in monkeys (Macaca nemestrina) by selective removal of the vascular endothelium with an intra-arterial balloon catheter. Immediately after de-endothelialization a platelet layer covers the denuded area. This thrombus is gradually removed and by 7 days the vessel appears to be largely reendothelialized. Beginning at day 4, smooth muscle cells undergo m...

Spontaneous Arteriosclerosis in Rabbits

Cerebral arteriosclerosis.

The Biology of Arteriosclerosis

The experimental approach to the study of arteriosclerosis has yielded disappointing results in comparison to the vast effort expended upon the problem. Any new method of attack excites interest, and it is the special virtue of this monograph to have placed in evidence, with great clarity and a profusion of beautiful illustrations, the existence of a rich intramural vascular plexus, which has a...